Volume No. :   8

Issue No. :  4

Year :  2018

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Extraction, Phytochemical Studies and In–Vitro Screening of the Leaves and Flowers of Crossandra infundibuliformis against Mycobacterium tuberculosis



Address:   Satheesh Kumar. G*, Noorjahan, G. Sadhana Reddy, Syed Khundmeer Mujahid, T. Ashwini, V. Mahender Chary
Department of Pharmaceutical Chemistry, Jyothishmathi College of Pharmacy, Turkapally (V), Shamirpet, (M) Medchal District, Telangana-500101.
*Corresponding Author
DOI No: 10.5958/2231-5659.2018.00041.3

ABSTRACT:
The present work was to extract and screen the leaves and flowers of Crossandra infundibuliformis against Mycobacterium tuberculosis. Crossandra infundibuliformis is distributed in India, Srilanka and other Asian countries. It has wide range of pharmacological and antimicrobial potentials. In present study, the leaf and flower extracts of Crossandra infundibuliformis were prepared based on polarity of solvents such as petroleum ether, ethyl acetate and methanol. The leaf and flower extracts were screened against Mycobacterium tuberculosis using Alamar blue TB assay method. Phytochemical investigation revealed the presence of secondary metabolites such as phenols, glycosides, alkaloids, tannins. The minimum inhibitory concentration of methanolic extract of flower and ethyl acetate extract of leaf is sensitive at 3.12µg/ml against Mycobacterium tuberculosis. This study reveals the first report of the anti-mycobacterial perspectives of leaf extracts of Crossandra infundibuliformis.
KEYWORDS:
Crossandra infundibuliformis, Mycobacterium tuberculosis, Secondary metabolites, Minimum inhibitory concentration, Alamar blue assay.
Cite:
Satheesh Kumar. G, Noorjahan, G. Sadhana Reddy, Syed Khundmeer Mujahid, T. Ashwini, V. Mahender Chary. Extraction, Phytochemical Studies and In–Vitro Screening of the Leaves and Flowers of Crossandra infundibuliformis against Mycobacterium tuberculosis. Asian J. Res. Pharm. Sci. 2018; 8(4):247-252.
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