Volume No. :   8

Issue No. :  1

Year :  2018

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Formulation and Evaluation of Rutin Loaded Nanosponges



Address:   K.Vijaya Sri*, Guda Santhoshini, D. Ravi Sankar, K.Niharika
Malla Reddy College of Pharmacy, (Affiliated to OsmaniaUniversity), Secunderabad, Telangana
*Corresponding Author
DOI No: 10.5958/2231-5659.2018.00005.X

ABSTRACT:
The main objective of this research was to develop rutin nanosponges and evaluate the potential of nanosponges for the delivery oral route. Rutin exhibited as antioxidant, anti-inflammatory, anti-allergic and antiviral activity. But its, poor absorption from the gastrointestinal tract is slow and irregular, probably due to their less solubility and slow dissolution rate. Rutin-loaded nanosponges were prepared by emulsion solvent diffusion method. Nanosponges were evaluated for various physicochemical parameters like FT-IR, DSC, entrapment efficiency ,SEM, particle size, zeta potential and in vitro drug release. FT-IR study reveals the there was no physical and chemical interaction observed between the excipients and drug in combination. Rutin-loaded nanosponges enhanced the drug release when compare to the pure rutin.
KEYWORDS:
Rutin Loaded Nanosponges
Cite:
K.Vijaya Sri, Guda Santhoshini, D. Ravi Sankar, K.Niharika. Formulation and Evaluation of Rutin Loaded Nanosponges. Asian J. Res. Pharm. Sci. 2018; 8(1):21-24.
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