Volume No. :   7

Issue No. :  2

Year :  2017

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Chitosan Based Sustained Release Mucoadhesive Buccal Patches Containing Amlodipine Besylate (AMB)



Address:   V Jhansipriya Marabathuni1*, P. Dinesh1, R. Ravikumar1, P. Yamini1, P. Sai Kiran1, Sd. P.Hussain1, Ch. M.M. Prasada Rao
1Department of Pharmaceutics, Bellamkonda Institute of Technology and Sciences, Podili.
2Department of Pharm. Chemistry, QIS College of Pharmacy, Ongole
*Corresponding Author
DOI No: 10.5958/2231-5659.2017.00015.7

ABSTRACT:
The buccal region of the oral cavity is an attractive target for administration of the drug of choice. Sustained release formulations have been developed and are gaining in popularity and medical acceptance. To increase bioavailability and prevent first pass metabolism of drug, Amlodipine besylate was embedded in sustained released buccal patch over period of 6 hour. The objective of present work was to characterize the effect of chitosan with PVP K-30 on water soluble drug by preparing mucoadhesive buccal patch. Each formulated batch was subjected to various evaluation parameters. The swelling percentage was found to be function of solubility of drug and PVP K-30. The mucoadhesive strength, vapour transmission and in-vitro released of water soluble drug through water insoluble chitosan base matrix were found satisfactorily. The AMB shows some suitability with those polymers.
KEYWORDS:
Buccal Patch, Sustained Drug Delivery, Bioadhesion, Mucoadhesive Buccal Delivery.
Cite:
V Jhansipriya Marabathuni, P. Dinesh, R. Ravikumar, P. Yamini, P. Sai Kiran, Sd. P.Hussain, Ch. M.M. Prasada Rao. Chitosan Based Sustained Release Mucoadhesive Buccal Patches Containing Amlodipine Besylate (AMB). Asian J. Res. Pharm. Sci. 2017; 7(2): 97-104.
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