Volume No. :   6

Issue No. :  4

Year :  2016

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Formulation and Evaluation of Baclofen Floating Tablets



Address:   Dasari Nirmala, Enjamuri Aslesha , M. Sudhakar
Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad -500100 Telangana State India affiliated to Osmania University.
*Corresponding Author
DOI No:

ABSTRACT:
The present study was carried out with an objective of formulation and evaluation of floating tablets of baclofen for prolongation of gastric residence time with a view to deliver the drug at controlled manner in gastrointestinal tract and consequently into systemic circulation. Baclofen, a centrally acting skeletal muscle relaxant, is indicated in the long-term treatment of spasticity resulting for multiple sclerosis and spinal cord injuries. Therefore baclofen floating tablets were prepared by direct compression method using 3 grades of Eudragit (Eudragit L100, Eudragit S100, and Eudragit RSPO). Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymers/excipient interactions. The prepared floating tablets were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, total floating time, water uptake (swelling index) and in-vitro dissolution studies. Among the 12 formulations F3 showed drug release 98.37% in pH 1.2 dissolution medium. All the formulations showed drug content ranging from 80.93 to 98.37%. Drug release rate kinetics studies shown that drug release follows Higuchi mechanism.
KEYWORDS:
Floating tablets, Floatation, sustained release, baclofen, direct compression, Eudragit.
Cite:
Dasari Nirmala, Enjamuri Aslesha , M. Sudhakar. Formulation and Evaluation of Baclofen Floating Tablets. Asian J. Res. Pharm. Sci. 2016; 6(4): 255-260.
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