Volume No. :   6

Issue No. :  3

Year :  2016

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Validated First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Lansoprazole and Aspirin in Tablet Dosage Forms



Address:   G. Kumaraswamy*, Repudi. Lalitha, D. Sudheer Kumar
Department of Pharmaceutical Analysis, Care College of Pharmacy, Athamakur (Mdl), Oglapur(V), Warangal (Dist), Telangana.
*Corresponding Author
DOI No: 10.5958/2231-5659.2016.00025.4

ABSTRACT:
The present work was aimed at method development and validation for simultaneous estimation of Lansoprazole and Aspirin by UV-Spectrophotometric method in pharmaceutical dosage form. In UV method Methanol as solvent and ?max of Lansoprazole and Aspirin were found to be 232nm and 222nm respectively. Concentration ranges were found to be 4-20µg/mL for both drugs. The R2 values were found to be 0.996 and 0.999 for Lansoprazole and Aspirin respectively. The method was validated statistically and by recovery studies. Percentage Assay and Recovery were found to be 95-105% for Lansoprazole and Aspirin. LOD and LOQ ranges were found to be 0.177 and 0.539µg/mL and 0.298 and 0.903µg/mL for Lansoprazole and Aspirin repectively. This method was validated using ICH guidelines.
KEYWORDS:
Aspirin, Lansoprazole, UV-Spectrophotometric method, Simultaneous equation, Validation
Cite:
G. Kumaraswamy, Repudi. Lalitha, D. Sudheer Kumar . Validated First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Lansoprazole and Aspirin in Tablet Dosage Forms. Asian J. Res. Pharm. Sci. 2016; 6(3): 185-190.
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