Volume No. :   6

Issue No. :  2

Year :  2016

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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UV Spectrophotometric Method Development and Validation of Fluticasone Propionate



Address:   Rajashri R. Kulkarni1*, Dipti G. Phadtare2, Ravindra B. Saudagar2
1Department of Quality Assurance Techniques, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik.
2Department of Pharmaceutical Chemistry, R. G. Sapkal College of Pharmacy, Anjaneri, Nashik.
*Corresponding Author
DOI No: 10.5958/2231-5659.2016.00019.9

ABSTRACT:
Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. Simple, precise and accurate UV spectroscopic method has been developed and validated for estimation of Fluticasone propionate. It is a selective agonist at the glucocorticoid receptor. UV spectroscopic method which is based on measurement of absorption of UV light, the spectra of Fluticasone propionate in methanol showed maximum wavelength at 236nm and calibration curve were plotted over the concentrations ranging from 2-22ug/ml of Fluticasone propionate with correlation coefficient 0.9812 validation was performed as per ICH Q2 (R1) guidelines for linearity, accuracy, precision and recovery. The proposed method was validated.
KEYWORDS:
UV Spectrophotometric, Fluticasone Propionate
Cite:
Rajashri R. Kulkarni, Dipti G. Phadtare, Ravindra B. Saudagar. UV Spectrophotometric Method Development and Validation of Fluticasone Propionate. Asian J. Res. Pharm. Sci. 2016; 6(2): 135-138.
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