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Asian Journal of Research in Pharmaceutical Sciences
ISSN: 2231-5659(Online), 2231-5640(Print)
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Formulation and Evaluation of Fast Dissolving Tablet of Drug Used In the Treatment of Motion Sickness
Satish Shinde*, Dharmendra Mundhada, Rajesh Mujoriya
Department of Pharmaceutics, Agnihotri College of Pharmacy, Wardha, Maharashtra
Fast dissolving tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or suspension. In the present study Fast dissolving tablet of Scopolamine Hydrobromide was prepared by direct compression method using Indion 414, Cross Carmellose Sodium and sodium starch glycolate as superdisintegrants. The tablets prepared was evaluated for various parameters like various density parameters, thickness, hardness, friability, disintegration time, wetting time and in-vitro dissolution time. All the parameters were found to be within limits. Indion 414 as superdisintegrant gives better result as compared to crosscarmellose sodium and Sodium starch glycolate. Tablets disintegrate within 30 sec in mouth having better mouth feel. The developed formulation of Scopolamine Hydrobromide batch F5 (10% Indion 414) showed good palatability and dispersed within 30 seconds as compared to Cross Carmellose Sodium and Sodium starch glycolate.
Fast dissolving tablets, Scopolamine Hydrobromide, Indion 414, superdisintegrant, palatability.
Satish Shinde, Dharmendra Mundhada, Rajesh Mujoriya. Formulation and Evaluation of Fast Dissolving Tablet of Drug Used In the Treatment of Motion Sickness. Asian J. Res. Pharm. Sci. 5(3): July-Sept.; Page 181-187.
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