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Asian Journal of Research in Pharmaceutical Sciences
ISSN: 2231-5659(Online), 2231-5640(Print)
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Pleiotropic Effects of Statins
Puja S. Gaikwad
Nayna V. Pimpodkar
Trushali A. Mandhare
Puja S. Gaikwad1*, Dhanshri U.Gadhave1, Nayna V. Pimpodkar2, Trushali A. Mandhare1
1Lecturer, College of Pharmacy (D.Pharm) Degaon, Satara, (MH) India- 415 004.
2Principal, College of Pharmacy (D.Pharm) Degaon, Satara, (MH) India- 415 004.
Statins are the most commonly prescribed drugs worldwide, are cholesterol lowering agents used to manage and prevent cardiovascular and coronary heart diseases. Recently a multifaceted actions in different physiological and pathological conditions has been also proposed for statins such as antiiflammation, neuroprotection etc. Statins have been shown to act through cholesterol dependant & independent mechanisms which are able to affect several tissue functions and modulate specific signal transduction pathways. Here we review the pharmacology of statins, providing a comprehensive update of the current knowledge of their effects on tissues, biological processes & pathological conditions; but statins are now becoming recognized as powerful anti-inflammatory agents that exert beneficial effects beyond low density lipoprotein cholesterol reduction.
Pleiotropic Effects of Statins.
Puja S. Gaikwad, Dhanshri U.Gadhave, Nayna V. Pimpodkar, Trushali A. Mandhare. Pleiotropic Effects of Statins. Asian J. Res. Pharm. Sci. 5(1): Jan.-March 2015; Page 55-58.
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