Volume No. :   4

Issue No. :  4

Year :  2014

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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In-Vivo Anti-Inflammatory and Analgesic Screening of Ficus bengalensis Leaf Extract in Rats



Address:   Prathap Kumar Kothapalli1, S. Jagadeesh Sanganal1, N. B. Shridhar1, H.D. Narayanaswamy2 and M. Narayanaswamy3
1Dept. of Veterinary Pharmacology and Toxicology, Veterinary College, Bangalore-560024, India
2Dept. of Veterinary Pathology, Veterinary College, Bangalore-560024, India
3Dept. of Veterinary Physiology, Veterinary College, Bangalore-560024, India
*Corresponding Author
DOI No:

ABSTRACT:
The present study was conducted to evaluate the analgesic and anti-inflammatory activities of Ficus bengalensis leaf extract in rats using Eddy’s hot plate method and formalin induced paw oedema model, respectively. The Ficus benghalensis methanolic leaf extract tested for anti-inflammatory activity, showed a significant (P<0.001) paw volume reduction at dose of 200 mg/kg and at 3 hours. The percent inhibition in paw volume was 65.21% at 200 mg/kg as compared to 62.31% of Diclofenac indicating the anti-inflammatory activity, in formalin-induced paw-edema model. The Ficus benghalensis leaf extract also demonstrated a significant (P<0.001) analgesic activity at both 100 and 200 mg/kg. Thus it can be concluded that the Ficus benghalensis leaf extract possess a potent analgesic and anti-inflammatory activities as reflected by the parameters investigated, and demands further research to characterize the novel candidate.
KEYWORDS:
Analgesic, Anti-inflammatory, Ficus bengalensis leaf extract, Eddy’s hot plate method and Formalin induced paw oedema model.
Cite:
Prathap Kumar Kothapalli, S. Jagadeesh Sanganal, N. B. Shridhar, H.D. Narayanaswamy, M. Narayanaswamy. In-Vivo Anti-Inflammatory and Analgesic Screening of Ficus bengalensis Leaf Extract in Rats. Asian J. Res. Pharm. Sci. 4(4): Oct.-Dec. 2014; Page 174-178.
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