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Asian Journal of Research in Pharmaceutical Sciences
ISSN: 2231-5659(Online), 2231-5640(Print)
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Development and Evaluation of Mucoadhesive Sustained Release Tablet using Tamarindus indica Gum
Manmohan S. Jangdey*
Anshita Gupta and Abhishek K. Sah
Manmohan S. Jangdey*, Anshita Gupta and Abhishek K. Sah
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C. G.) 492001, India
In the present work, the mucoadhesive tablet of diclofenac (as a model drug) by using Tamarindus indica fruit gum as a binder was formulated. The preliminary evaluation of Tamarindus indica gum showed that bulk density 0.50 ± 0.4 g/cm3, tapped density 0.35 ± 0.8 g/cm3 and angle of repose 280 ± 0.26. The six tablet formulation were prepared by using 0.25%, 0.50%, 0.75%, 1%, 1.25% and 1.50% w/w of Tamarindus indica gum by direct compression (F1,F2,F3,F4 and F5 respectively). Tablets were subjected for evaluation of uniformity of weight, hardness, friability, drug content uniformity, swelling behaviour, release rate study, mucoadhesive study, and tensile strength study. Formulation was studied for drug additive interaction (FTIR). F4 is found to be optimized formulation. The in-vitro drug release of F4 formulation exhibits complete release of Diclofenac Sodium with nonfiction first order release kinetic. The formulation F4 exhibited tensile strength 0.27 N with 10 hrs of mucoadhesion. From the study it can be conclude that the Tamarindus indica gum used as mucoadhesive sustained release tablet.
Development and Evaluation of Mucoadhesive Sustained Release Tablet using Tamarindus indica Gum.
Development and Evaluation of Mucoadhesive Sustained Release Tablet using Tamarindus indica Gum. Asian J. Res. Pharm. Sci. 4(2): April-June 2014; Page 77-82.
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