Volume No. :   4

Issue No. :  1

Year :  2014

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Formulation and Evaluation of Gastric Floating Tablet of Domperidone



Address:   Raut Indrayani D.1*, Bandgar Sandip A.2, Shah R. R.3, Chougule D.D.3
1Rajarambapu College of Pharmacy, Kasegaon.
2Ashokrao Mane College of Pharmacy, Peth-Vadgaon, Dist. Sangli
3Appasaheb Birnale College of Pharmacy, Sangli.
*Corresponding Author
DOI No:

ABSTRACT:
Floating dosage forms enable the sustained delivery of drugs in the gastro-intestinal tract. The purpose of this investigation was to prepare a gastro-retentive drug delivery system of Domperidone which is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. Floating tablets of Domperidone were prepared by employing HPMC K 100 M and Xanthan gum as a Hydrophilic sustained release polymers, Ethyl Cellulose as a hydrophobic floating enhancer, Sodium bicarbonate as a gas-generating agent in formulations. Domperidone floating tablets were evaluated for in vitro Dissolution and in vitro buoyancy study. Evaluation of powder like angle of repose, bulk density, tapped density, Carr’s compressibility index and Hausners ratio was evaluated. Evaluation of tablets i.e. diameter, thickness, friability, hardness, average weight, content uniformity, swelling characteristics and dissolution study were also performed. The prepared tablets exhibited satisfactory physico-chemical characteristics. All the prepared batches showed good in vitro buoyancy. The tablet swelled radially and axially during in vitro buoyancy studies. It was observed that the tablet remained buoyant for 12 hours. The drug release from the tablets was sufficiently sustained.
KEYWORDS:
Domperidone, Floating tablet, In vitro buoyancy.
Cite:
Raut Indrayani D., Bandgar Sandip A., Shah R. R., Chougule D.D.. Formulation and Evaluation of Gastric Floating Tablet of Domperidone. Asian J. Res. Pharm. Sci. 4(1): Jan.-Mar. 2014; Page 22-25.
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