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Asian Journal of Research in Pharmaceutical Sciences
ISSN: 2231-5659(Online), 2231-5640(Print)
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Formulation and Evaluation of Zidovudine Loaded Microsphere
Alok Pal Jain
Atul Bisen*, Dr Alok Pal Jain, Suchit Jain
Department of Pharmaceutics, Guru Ramdas Khalsa Institute of Sciences and Technology, Jabalpur (M.P.)
In the present study a satisfactory attempt was made to develop microparticulate drug delivery system of zidovudine with improved bioavailability, efficient targeting and dose reduction. From the experimental results demonstrated that Chitosan polymer is a suitable macromolecule for the preparation of microspheres of Zidovudine. Particle size analysis revealed that the microspheres were in the range (172 to 192µm) and all the formulations showed ideal surface methodology. Present study shows that the targeting efficiency of drug loaded microspheres over free drug was higher which may provide increased therapeutic efficacy.
Zidovudine, bioavailability, Chitosan, Microspheres, therapeutic efficacy.
Atul Bisen, Alok Pal Jain, Suchit Jain. Formulation and Evaluation of Zidovudine Loaded Microsphere. Asian J. Res. Pharm. Sci. 2013; Vol. 3: Issue 4, Pg 200-205.
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