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Asian Journal of Research in Pharmaceutical Sciences
ISSN: 2231-5659(Online), 2231-5640(Print)
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Design Formulation and Evaluation of Reservoir Type Controlled Released Moxifloxacin Hydrochloride Ocular Insert
Ramesh B. Parmar
H. M. Tank
Ramesh B. Parmar1*, Dr. H. M. Tank2
1S. J. Thakkar Pharmacy College, Opp NRI bungalow, Avadh Club Road, Munjka, Kalawad Road, Rajkot.
2Matushree V B Manvar Pharmacy College, Dumiyani, Upleta, Rajkot.
The present studies were mainly focus to developed ocular controlled release formulation of Moxifloxacin Hydrochloride. Reservoir type of ocular insert was developed by solvent casting method. Total nine formulations was developed using different ratio of Eudragit RS 100 and Eudragit RL100 in combination as a rate controlling membrane and reservoir was prepared by using sodium CMC. All the prepared formulation were subjected for evaluation of physicochemical parameter like thickness, weight variation, percentage moisture absorption, percentage moisture loss, surface pH, sterility, drug content and anti-microbial activity. Evaluated results were shown that all the prepared formulation was suitable for patient compliance. In-vitro release study was carried out by using commercial semi-permeable membrane with the help of modified standard cylindrical tube method and best formulation F7 found 98.21 % at the end of 24 hrs. Formulated ocular inserts also passed the test for sterility. The above in vitro release studies revealed that the best ocular inserts formulation followed near to zero-order release kinetics. Higuchi’s plot and Peppa’s plot revealed that the mechanism of drug release involved in all the formulations was super case II transport diffusion. The antimicrobial study was shown that formulation was able to inhibit the microbial growth for extended period of time. The controlled release ocular insert was more suitable as compared to conventional dosage form.
Reservoir drug delivery system, ocular insert, Moxifloxacin Hydrochloride, Eudragit RS100, Eudragit RL 100
Ramesh B. Parmar, H. M. Tank. Design Formulation and Evaluation of Reservoir Type Controlled Released Moxifloxacin Hydrochloride Ocular Insert. Asian J. Res. Pharm. Sci. 3(1): Jan.-Mar. 2013; Page 19-24.
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