Volume No. :   2

Issue No. :  4

Year :  2012

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Screening of Thrombolytic Activity of Bougainvillea glabra Leaves Extract by In-Vitro



Address:   A. Elumalai*, M. Chinna Eswariah, Vidhyulatha Chowdary CH, Ranjith Kumar, Anusha M, Naresh K.
Department of Pharmacognosy, Anurag Pharmacy College, Ananthagiri (V), Kodad(M), Nalgonda (Dt), Andhra Pradesh, India, 508 206.
*Corresponding Author
DOI No:

ABSTRACT:
Investigation with the crude methanolic extract of Bougainvillea glabra carried out to evaluate its possible thrombolysis activity. Myocardial or cerebral infractions are the serious consequences in Atherothrombotic diseases leading to death and the side effects produced by consecutive use of thrombolytic agent like t-PA, Urokinase and streptokinase to treat these diseases has become a global concern. Extraction was carried out using Soxhlet apparatus. The crude methanolic extract was found to have significant thrombolytic activity at a dose of 800ยต g/ml with a maximum effect comparable with Streptokinase as a positive control and water as a negative control.
KEYWORDS:
Bougainvillea glabra, thrombolysis activity, Streptokinase.
Cite:
A. Elumalai, M. Chinna Eswariah, Vidhyulatha Chowdary CH, Ranjith Kumar, Anusha M, Naresh K.. Screening of Thrombolytic Activity of Bougainvillea glabra Leaves Extract by In-Vitro. Asian J. Res. Pharm. Sci. 2(4): Oct.-Dec. 2012; Page 134-136.
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