Volume No. :   2

Issue No. :  2

Year :  2012

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Combating Pseudomonas aeruginosa Biofilms by Potential Biofilm Inhibitors



Address:   Hisham A. Abbas*, Fathy M. Serry, Eman M. EL-Masry
Department of Microbiology and Immunology-Faculty of Pharmacy-Zagazig University- Zagazig- Egypt
*Corresponding Author
DOI No:

ABSTRACT:
Ten potential antibiofilm agents (N-acetylcysteine (NAC), ambroxol, piroxicam, diclofenac sodium, ketoprofen, 4-nitropyrdidine-N-oxide (4NPO), sodium ascorbate, sucralose, xylitol and sorbitol) showed varied activity against pre-formed biofilms formed by twenty clinical isolates of Pseudomonas aeruginosa as demonstrated by minimum biofilm inhibitory concentration (MBIC). 4NPO was the most active; Diclofenac sodium, ketoprofen, N-acetylcysteine, ambroxol, sodium ascorbate and piroxicam showed moderate activity, while sucralose, xylitol, and sorbitol demonstrated weak activity.
KEYWORDS:
Pseudomonas aeruginosa, biofilm inhibition, antibiofilm agents
Cite:
Hisham A. Abbas, Fathy M. Serry, Eman M. EL-Masry . Combating Pseudomonas aeruginosa Biofilms by Potential Biofilm Inhibitors . Asian J. Res. Pharm. Sci. 2(2): April-June 2012; Page 66-72.
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