Volume No. :   2

Issue No. :  1

Year :  2012

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Anti-diarrhoeal, antispasmodic and phytochemical properties of ethanol extract of the leaves of Ficus exasperate



Address:   Chinedu Fred Anowi1, Uyai Umanah2, A.U. Emezie3, AU Utoh-Nedosa4
1Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka
2Department of Pharmaceutical Pharmaceutics and Pharmaceutical Microbiology , Faculty of Pharmacy, Madonna University, Elele.
3Department of Pharmacognosy and Traditional Medicine, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka
4Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka
*Corresponding Author
DOI No:

ABSTRACT:
Aim - Ficus exasperata has been claimed to have medicinal and ethnopharmacological properties. The people of Efik in Calabar South Local Government Area of Cross River State, Nigeria used it to manage frequent stooling. This study is therefore aimed at determining this claim using the leaves of Ficus exasperata which will also serve as criteria to recommend the ethno pharmacological uses of the plant. Methodology - The leaves were dried, powdered and extracted with ethanol for 48hrs at room temperature with constant shaking using mechanical shaker. This was concentrated using rotary evaporator. Phytochemical screening revealed the presence of alkaloid, steroids, tannins, flavonoids, saponins and glycoside. Antidiarrhea activity of the extract was carried out which was compared to a standard drug (loperamide) using castor oil to induce diarrhoea. Antispasmodic activity of the extract was also carried out which was compared with a standard drug using charcoal meal test. Result – Ficus exasperata decreases bowel’s movement and controls diarrhoea in experimental rats when compared with standard drugs using standard experimental procedures. Conclusion – The leaves of Ficus exasperata exhibit, antispasmodic and antidiarrhea properties.
KEYWORDS:
Ficus exasperate, loperamide, charcoal meal, castor oil
Cite:
Chinedu Fred Anowi, Uyai Umanah, A.U. Emezie, AU Utoh-Nedosa. Anti-diarrhoeal, antispasmodic and phytochemical properties of ethanol extract of the leaves of Ficus exasperate. Asian J. Res. Pharm. Sci. 2(1): Jan.-Mar. 2012; Page 26-32.
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