Volume No. :   1

Issue No. :  4

Year :  2011

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Synthesis and Evaluation of Antioxidant Activities of Some Novel Isatin Derivatives and Analogs



Address:   C.R. Prakash1*, S. Raja1, G. Saravanan2, P. Dinesh Kumar3 and T. Panneer Selvam4
1Department of Pharmaceutical Chemistry, DCRM Pharmacy College, Inkollu. Andhra Pradesh, India.
2Medicinal Chemistry Research Laboratory, Bapatla College of Pharmacy, Bapatla-522 101, (A.P), India.
3Dep. of Pharmaceutics, Rahul Institute of Pharmaceutical Science and Research, Chirala-523157, (A.P.), India.
4Department Pharmaceutical Chemistry, Srinivas College of Pharmacy, Mangalore-574142, Karnataka, India.
*Corresponding Author
DOI No:

ABSTRACT:
In the present study, a series of novel Schiff bases of isatin were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy, and elemental analysis. These compounds were screened for antioxidant activity by DPPH radical scavenging activity. In this method, the compound 3-(4-(4-dimethylaminobenzylideneamino) phenylimino) indoline-2-one (5c) showed highest antioxidant activity because of the presence of electron donating group.
KEYWORDS:
antioxidant, isatin; Schiff base.
Cite:
C.R. Prakash, S. Raja, G. Saravanan, P. Dinesh Kumar, T. Panneer Selvam. Synthesis and Evaluation of Antioxidant Activities of Some Novel Isatin Derivatives and Analogs. Asian J. Res. Pharm. Sci. 1(4): Oct.-Dec. 2011; Page 140-143.
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