Volume No. :   1

Issue No. :  3

Year :  2011

ISSN Print :  2231-5640

ISSN Online :  2231-5659


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Tylophora asthmatica L. Prevents Lipid Peroxidation in Acetaminophen Induced Hepato Toxicity in Rats



Address:   R. Malathi1 S. Ahamed John2 and A.Cholarajan3
1Department of Biotechnology, Bharathidasan University College (w), Orathanadu, Thanjavur, Tamilnadu, India.
2Department of Botany, Jamal Mohamed College, Trichy, Tamilnadu, India.
3Department of Microbiology, Meenakshi Chandrasekaran College of Arts and Science, Pattukkottai – 614 626, Thanjavur, Tamilnadu, India.
*Corresponding Author
DOI No:

ABSTRACT:
Methanolic extract of Tylophora asthmatica leaves were prepared and tested for its antilipidperoxidation effect against acetaminophen induced hepato toxicity in rats. Alteration in the levels of lipid peroxide, iron, ferritin, total cholesterol, total lipid and phospholipids were tested in both experiment and control group of rats. Acetaminophen [1gm/kg] has showed a significant increase [p<0.05] in experimental rats except the level of phospholipids, which showed a significant decrease [p<0.05] compared to control rats. Treatment with methanolic extract of Tylophora asthmatica leaves [200mg/kg] has brought back the altered levels of this parameter to the near normal levels in the dose dependent manner.
KEYWORDS:
Acetaminophen, Hepatoprotective, Tylophora asthmatica.
Cite:
R. Malathi S. Ahamed John, A.Cholarajan. Tylophora asthmatica L. Prevents Lipid Peroxidation in Acetaminophen Induced Hepato Toxicity in Rats. Asian J. Res. Pharm. Sci. 1(3): July-Sept. 2011; Page 71-73.
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