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Asian Journal of Research in Pharmaceutical Sciences
ISSN: 2231-5659(Online), 2231-5640(Print)
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Determination of LC50 Values of Extracts of Euphorbia hirta Linn and Euphorbia nerifolia Linn Using Brine Shrimp Lethality Assay
Sandeep B. Patil
Chandrakant S. Magdum
Sandeep B. Patil1* and Chandrakant S. Magdum2
1Appasaheb Birnale college of Pharmacy, South Shivaji nagar, Sangli 416 416.
2Rajarambapu College of Pharmacy, Kasegaon, Sangli
Brine shrimp lethality assay is an important tool for preliminary assessment of cytotoxicity of herbal drugs. This method is used for the determination of LC50 values of herbal extracts. In this study, extract of Euphorbia hirta Linn and Euphorbia nerifolia Linn, which are reported in traditional literature for their anti-tumour activity, had been selected to test for brine shrimp lethality activity. This experimentation shows that the LC50 of ethyl acetate and acetone extract of Euphorbia hirta Linn and methanolic extract Euphorbia nerifolia Linn are found to be 71.15, 92.15 and 49.55ug/ml respectively.
Brine shrimp lethality assay, Euphorbia hirta Linn, Euphorbia nerifolia Linn
Sandeep B. Patil, Chandrakant S. Magdum. Determination of LC50 Values of Extracts of Euphorbia hirta Linn and Euphorbia nerifolia Linn Using Brine Shrimp Lethality Assay. Asian J. Res. Pharm. Sci. 1(3): July-Sept. 2011; Page 69-70.
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